Cambridge Healthtech Institute’s 13th Annual
Advances in Purification & Recovery
Beyond the Platform: Optimizing Downstream Efficiency for Complex Biologics
June 16-17, 2027
Purification and recovery strategies are changing quickly to keep pace with a more diverse biologics pipeline. The Advances in Purification & Recovery conference brings together purification scientists and process engineers to address the full scope of downstream challenges, from multispecific antibodies and next-generation conjugates to AAV, lentiviral vectors, mRNA and plasmid DNA. Sessions will also highlight advances in membranes, novel resins, continuous downstream processing, and the growing role of mechanistic modelling and digital twins in purification process design. Attendees will gain tools to design robust, scalable purification processes faster, with less material and lower cost.
Coverage will include, but is not limited to:
- COMPLEX ANTIBODY FORMATS: BI/TRI/TETRA-SPECIFICS
- Molecule-specific purification strategies and mispaired-species removal during capture chromatography
- Mixed-mode polishing for bispecific impurity clearance
- Linker stability, aggregation, and pairing in tri/tetraspecifics
- NEXT-GENERATION CONJUGATES
- Free-payload and DAR-species clearance in ADC purification
- Platform purification for peptides-drug conjugates
- Radioconjugate-specific handling and purification
- Novel conjugate combinations (AOCs, PDCs, oligo/peptide conjugates)
- Targeted LNPs—antibody-conjugated LNPs for mRNA delivery
- AAV/VIRAL VECTOR PURIFICATION
- Affinity capture ligand selection across AAV serotypes
- Polishing of viral vectors
- Purification differences between HEK293 transient transfection and producer cell line platforms
- PURIFICATION OF mRNA, siRNA, circularRNA, CELL AMPLIFYING RNA, PDNA
- Chromatography for mRNA capture
- dsRNA impurity removal strategies
- Anion-exchange purification of plasmid DNA
- Ion-pair reversed-phase purification of therapeutic oligonucleotides
- Circularization method choice and its impact on circular RNA purification
- ADVANCES IN PROCESS CHROMATOGRAPHY
- Convective membrane adsorbers for bind-elute and flow-through
- Prediction of chromatography performance from high throughput data
- Prepacked cassette formats for resins and filters
- Next-gen Protein A resins with surface-bound ligands vs. porous beads
- Membrane chromatography for bacteriophages, oncolytic viruses and VLPs
- AI/ML, MECHANISTIC AND HYBRID MODELING & DIGITAL TWINS IN DOWNSTREAM PROCESSING
- Mechanistic models for chromatography and downstream unit operations
- Hybrid mechanistic-machine learning process optimization models
- End-to-end digital twins across connected downstream operations
- ML applications in downstream process monitoring, prediction, and optimization
- AI for designing and screening chromatography experiments
The deadline for priority consideration is November 20, 2026.
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
Opportunities for Participation:
- To submit a podium presentation, please click here.
- To become a sponsor, click here.
- To present a poster, click here.
- To sign up to attend, click here.