Cambridge Healthtech Institute’s 21st Annual
Cell Line Engineering & Development
Improving Productivity and Product Quality
August 18-19, 2025
Join us at the Cell Line Engineering & Development conference to explore the latest innovations and advancements in the field. Key topics include gene editing technologies, the development of "clean CHO" lines for enhanced stability, AI-driven clone selection as well as site-specific vs. random integration strategies. This conference offers a unique opportunity to engage with the most pressing topics and innovations in the field, providing valuable insights for scientists to advance their work in cell line engineering and biopharmaceutical development.
Coverage will include, but is not limited to:
- Host Cell Line Engineering
- Advances in gene editing technologies (e.g., CRISPR, MAD7 nuclease)
- Development of "clean CHO" lines for enhanced stability and reduced contaminants
- Engineering for improved metabolic and glycosylation patterns
- Development of non-CHO mammalian systems (e.g.; human cell lines) for specific biologics
- Vector Design & Transfection
- Site-specific versus random integration techniques
- Use of transposon-based systems (e.g.; PiggyBac) for stable expression
- Using AI to examine how sequence affects expression
- AI and Automation in Clone Selection and Screening
- AI/ML applications for selecting high-performing clones
- Automated single-cell cloning and imaging tools
- Cell Line Development for Complex Biologics
- Strategies for bispecifics, trispecifics, and difficult-to-express proteins
- Chain balancing in bi/multispecific antibody production
- Developing cell lines for RNA therapeutics
- Cell line engineering for viral vectors
- Cell Line Development for Intensified and Perfusion Processes
- Selecting clones with robust growth under continuous conditions
- Ensuring stability against prolonged culture durations
- Maintaining high cell densities
- Scalability considerations and potential impacts on product quality
The deadline for priority consideration is January 27, 2025.
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
Opportunities for Participation: