Cambridge Healthtech Institute’s 22nd Annual
Cell Line Development & Engineering
Engineering Cells That Deliver
August 11-12, 2026
The Cell Line Development & Engineering conference brings together experts driving innovation in vector design, host-cell engineering, clone selection, and AI/ML-enabled cell-line development. The program covers advanced strategies for complex biologics including bispecifics, ADCs, viral vectors, DTE proteins, and RNA therapeutics. Attendees will explore cutting-edge approaches in genome editing, glycoengineering, process-fit cell lines, high-throughput clone selection, and predictive modeling for stability and productivity. This conference equips scientists with practical strategies to boost productivity, ensure stability, and accelerate translation from discovery to manufacturing.
Coverage will include, but is not limited to:
- Vector Design & Optimization for Complex Biologics
- Vector optimization: targeted integration, landing pads, transposon systems
- Promoter engineering and chain balancing for complex bispecifics, trispecifics, and DTE proteins
- Engineering Host Cell Lines
- Engineering for process fit: perfusion-ready, low-lactate, intensified platforms
- Genome editing and CRISPR-based cell-line engineering (CRISPR/Cas9, ZFN, TALENs)
- Gene knockouts/knock-ins to enhance productivity and/or product quality
- Glyco-optimization, metabolic pathway optimization
- Innovations in new CHO host cell lines
- Cell-free protein synthesis
- Clone Selection, Stability and High-Producer Cell Lines
- Engineering CHO for high-density perfusion clones and intensified fed batch
- Predicting stability, high-productivity clones using automation and HTS
- Predicting CHO cell-line stability using molecular markers and omics-based approaches
- Bispecifics, ADCs, Viral Vectors, and DTE Molecules
- Complex antibodies, multispecifics, and DTE proteins: minimizing mispairing and homodimers
- Cell-line stability, clone selection, and high-throughput workflows for difficult-to-express (DTE) and complex formats
- Engineering host cells for site-specific conjugation for ADCs and non-natural amino acids
- Cell-line development for gene therapy/viral vectors
- AI/ML for Cell-Line Engineering
- Predictive modeling of cell behavior, DTE detection, manufacturability prediction
- AI/ML and automation in cell-line development and early developability
The deadline for priority consideration is January 23, 2026.
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
Opportunities for Participation: