Cell Line Development & Engineering | The Bioprocessing Summit

Session Block

ENGINEERING HOST CELL LINES

KEYNOTE PRESENTATION: Cell Line Design Strategies for Improving Biotherapeutic Expression

Photo of Jack J Scarcelli, PhD, Senior Director, Head of Cell Line Development, Sanofi , Senior Director, Head of Cell Line Development , Sanofi — Jack J Scarcelli, PhD, Senior Director, Head of Cell Line Development, Sanofi , Senior Director, Head of Cell Line Development , Sanofi

What Does Secretion Look Like in a Single Cell?

Photo of Nathan E. Lewis, PhD, GRA Eminent Scholar and Professor, Center for Molecular Medicine Complex, Department of Biochemistry and Molecular Biology, University of Georgia , GRA Eminent Scholar & Professor , Biochemistry & Molecular Biology , University of Georgia — Nathan E. Lewis, PhD, GRA Eminent Scholar and Professor, Center for Molecular Medicine Complex, Department of Biochemistry and Molecular Biology, University of Georgia , GRA Eminent Scholar & Professor , Biochemistry & Molecular Biology , University of Georgia

Photo of Jean-Sebastien Maltais, PhD, Research Officer, Medical Devices, National Research Council Canada , Research Officer , Medical Devices , Natl Research Council Canada — Jean-Sebastien Maltais, PhD, Research Officer, Medical Devices, National Research Council Canada , Research Officer , Medical Devices , Natl Research Council Canada

Photo of Laura Zielewicz, PhD, Principal Scientist, Pfizer Inc. , Principal Scientist , Pfizer — Laura Zielewicz, PhD, Principal Scientist, Pfizer Inc. , Principal Scientist , Pfizer

Claire Pearce, PhD, Associate Director, Head of Mammalian Expression, Technologies Centre of Excellence (MET CoE), GSK , Associate Director, Head of Mammalian Expression , Technologies Centre of Excellence (MET CoE) , GSK

CLONE SELECTION, STABILITY, AND HIGH PRODUCING CELL LINES

KEYNOTE PRESENTATION: Adaptive Development: Aligning Cell-Line Optimization with Process Improvements for Enhanced Speed and Productivity

Photo of Christina S. Alves, PhD, Head, US Biologics Process Development, Takeda , Head, US Biologics Process Development , Takeda — Christina S. Alves, PhD, Head, US Biologics Process Development, Takeda , Head, US Biologics Process Development , Takeda

Screening Methods to Identify Clones with Favorable Meabolis Signatures

Hillary Miller, PhD, Principal Scientist, Cell Engineering and Analytical Sciences, Johnson & Johnson Innovative Medicine , Principal Scientist , Cell Engineering and Analytical Sciences , Johnson & Johnson Innovative Medicine

Photo of Susan Sharfstein, PhD, Professor of Nanoscale Science and Engineering, University at Albany , Professor , Nanoscale Science and Engineering , University at Albany — Susan Sharfstein, PhD, Professor of Nanoscale Science and Engineering, University at Albany , Professor , Nanoscale Science and Engineering , University at Albany

Photo of Jackson Leong, PhD, Senior Scientist, Cell Culture Process Development, Denali Therapeutics Inc. , Senior Scientist , Cell Culture Process Development , Denali Therapeutics Inc — Jackson Leong, PhD, Senior Scientist, Cell Culture Process Development, Denali Therapeutics Inc. , Senior Scientist , Cell Culture Process Development , Denali Therapeutics Inc

VECTOR DESIGN AND OPTIMIZATION

Plasmid Engineering for AAV Production and Increased Safety

Photo of Azadeh Sarfallah, PhD, Senior Scientist, Applied Viral Sciences, Genentech Inc. , Sr Scientist , Applied Viral Sciences , Genentech Inc — Azadeh Sarfallah, PhD, Senior Scientist, Applied Viral Sciences, Genentech Inc. , Sr Scientist , Applied Viral Sciences , Genentech Inc

Shuang Wei, PhD, Senior Scientist, Merck , Senior Scientist , Merck

Photo of Metewo Selase Enuameh, PhD, Associate Director, Vector Core Cell Line Development, REGENXBIO, Inc. , Associate Director , Vector Core Cell Line Development & Engineering , REGENXBIO Inc — Metewo Selase Enuameh, PhD, Associate Director, Vector Core Cell Line Development, REGENXBIO, Inc. , Associate Director , Vector Core Cell Line Development & Engineering , REGENXBIO Inc

In recombinant Adeno-Associated Virus (rAAV) delivered gene therapy, continuous improvement of established manufacturing processes to optimize product quality and production yields is desirable to further reduce manufacturing costs and regulatory risks. Using cell line development and engineering, plasmid and process optimization, plus technological advancements and innovation, we demonstrate how we achieved our current state of the art NAVXpressÂ® platform process, as we continue to innovate further for future enhancements of our next generation production processes, while maintaining high product purity.