Cambridge Healthtech Institute’s 21st Annual
Cell Culture Optimization & Scale-Up
Achieving Excellence at Every Scale
August 20-21, 2025
The Cell Culture Optimization and Scale Up conference brings together bioprocess experts to tackle key challenges in upstream processing. Learn practical strategies for optimizing cell culture conditions, scaling up from bench to commercial production, media optimization for intensified processes, as well as cutting-edge technologies like PAT, digital twins, and predictive modeling for process control.
Coverage may include, but is not limited to:
- Media and Feed Optimization
- Development of chemically-defined and animal-free media
- Optimizing media-feed strategies to support high-cell densities
- Advanced process control for monitoring feeding strategies
- Strategies to support perfusion/intensified fed-batch cultures
- Bioreactor Process Development and Scale-Up
- Strategies for consistent mixing, oxygen transfer, and pH balance
- Computational fluid dynamics
- Maintaining critical process parameters and addressing inconsistencies during scale-up
- Tech transfer from single-use to stainless steel bioreactor –parameter adjustments for scale and bioreactor differences
- Modality-specific scale-up challenges
- What can we learn from cultured meat?
- Microbial Upstream Process Challenges
- E. coli and bacteria for recombinant proteins and peptides
- Yeast and fungi for recombinant proteins and peptides
- Production of proteins with non-canonical amino acids
- PAT and Advanced Process Control for Real-time Bioreactor Process Monitoring
- Use of sensors and digital twins for predictive modeling
- Sensing specific metabolites or intracellular components and lag analysis
- Sensor reliability: Fouling, drift, to improve accuracy and precision
- Data integration: Combining data from different sensors, batch records, and process for real-time control
- Non-linear dynamics, time delays, multi-variable interactions and model dependency
The deadline for priority consideration is January 27, 2025.
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
Opportunities for Participation: