Cambridge Healthtech Institute’s 11th Annual
Intensified and Continuous Bioprocessing
Driving Efficiency, Cost, and Sustainability
August 18-19, 2025
The Intensified and Continuous Bioprocessing conference will once again bring industry leaders together to explore breakthrough strategies for process intensification and continuous processing across diverse modalities. Discussions will focus on overcoming key challenges such as product quality differences between batch and continuous modes, scalability for intensified processes, and integration of upstream and downstream operations. With special sessions on sustainability, PAT, and digital twins, this conference equips attendees with practical solutions to tackle bottlenecks and optimize production efficiency.
Coverage will include, but is not limited to:
- Process Intensification Strategies
- Combining perfusion and fed-batch processes to boost yield and reduce costs
- High-cell-density harvests and clarification
- Use of N-1 perfusion to generate dense cell cultures for downstream processing
- Intensified processing for non-mAb biologics - viral vectors, RNA (SMB or crystallization), vaccines, and multispecific antibodies
- Continuous processing of microbial products
- Integrated Bioprocessing
- Combining upstream perfusion bioreactors with continuous downstream systems
- Use of modular and hybrid bioreactor configurations combining batch and continuous technologies
- How to intensify based on existing/legacy equipment
- Integrated processing combining multiple unit operations from upstream, downstream, to fill/finish
- Challenges and Bottlenecks
- Differences in product quality between batch and continuous modes
- Challenges with residence times and batch holding times
- Scalability for intensified processes
- Strategies to adapt intensified processes for smaller-scale facilities or emerging markets
- Regulatory hurdles for fully continuous downstream processes
- Sustainability and Lifecycle Analysis
- Use of green metrics to evaluate environmental impact
- Comparison of batch vs intensified processes and their environmental impact
- Strategies to minimize waste, reduce water and solvent use, and recycle plastics
- DoE and process design to reduce PMI in biomanufacturing
- Life-cycle assessment of a molecule-to-drug’s environmental impact
- AIML, Automation, and Continuous Monitoring
- Process modeling to assess intensification feasibility and areas for intensification
- PAT for continuous monitoring of Critical Quality Attributes (CQAs)
- AI/ML applications for process control, modeling, and dynamic optimization
- Digital twins for predictive modeling and process simulation
The deadline for priority consideration is January 27, 2025.
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
Opportunities for Participation: