Cambridge Healthtech Institute’s 3rd Annual
Next-Generation Analytical Methods
New Technologies to Support the Characterization of Complex Biologics
August 12-13, 2026
For 2026, the Next-Generation Methods track explores the forefront of analytical innovation for biologics, highlighting strategies to streamline workflows and enhance data-driven decision-making. Sessions will focus on advances in automation, from miniaturized, flexible systems to end-to-end solutions that increase throughput and enable parallel analysis. Attendees will examine emerging technologies, including expanded MAM workflows, single-cell analysis, molecular dynamics simulations, and real-time monitoring of protein interactions. The track will also cover mass spectrometry innovations, such as ion mobility, proteoform-resolved approaches, and single-particle analysis, alongside structure–function studies that leverage AI/ML, cryo-EM, and advanced microscopy to guide CQA identification, method development, and risk assessment for novel and complex modalities.
Coverage will include, but is not limited to:
Automation Strategies
- Advances in automated and semi-automated tools for sample handling
- Emerging capabilities: batching/parallel analysis, increasing capacity and throughput, new instrument automations
- In pursuit of end-to-end automation systems
- Simple “mini-automation” approaches to facilitate flexibility and ease of use
Challenges and Gaps for Novel Biotherapeutics
- Characterization of next-generation gene editing and gene regulation modalities
- Identification and measurement of CQAs for new modalities
- Platforms for complex biologics (novel conjugations, multispecifics, fusions)
Emerging Technologies
- Expanded MAM applications and technologies; NGS integration in MAM workflows
- Increasing applications of traditional methods in GMP environments
- Molecular dynamics simulations
- Realtime analysis of protein-protein interactions
- Single cell analysis
- Ultra-sensitive analytical methods
Expanding and Optimizing MS Analytics
- Automation and digitalization impacts on MS analysis and interpretation
- Ion mobility separations
- Proteoform-resolved MS approaches (intact, subunit, top-down)
- Single-particle MS platforms
Structure-Function Analysis in CMC Analytics
- AI/ML structure prediction and modeling
- Applications of cryo-EM and advanced microscopy in analytical development
- CQA identification and risk assessment
- Modality-specific applications
- Support of method development and assay selection
The deadline for priority consideration is January 23, 2026.
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
Opportunities for Participation: