Cambridge Healthtech Institute’s Inaugural
SYMPOSIUM: CMC for ADCs & Next-Generation Conjugates
From Conjugation to Commercial Manufacturing
Monday, August 10, 2026
This one- day symposium delivers a comprehensive exploration of CMC strategies for ADCs and next-generation conjugates, covering advances in conjugation chemistry, analytical control, formulation, safety, and scale-up manufacturing. As the field of targeted therapeutics rapidly expands, ADCs and next-generation conjugates are pushing the boundaries of what is possible in drug design, potency, and precision. This conference brings together the critical CMC considerations that underpin their successful development by combining insights on process development, analytical control, containment, and integrated manufacturing.
Coverage will include, but is not limited to:
- Conjugation Process, Scale-up, and Manufacturing
- Site-specific vs. stochastic conjugation — defining and controlling CPPs
- Scale-up of conjugation and purification
- Controlling and optimizing DAR distribution
- PAT for real-time conjugation monitoring
- Purification and process optimization
- End-to-end manufacturing strategies
- Next-Generation Conjugate Formats and their CMC Challenges
- Bispecific ADCs — CMC requirements for dual-targeting platforms
- Dual-payload ADCs — conjugation challenges
- Immunostimulatory ADCs — CMC requirements for immune-activating payloads
- Degrader-antibody conjugates — manufacturing approaches for protein degrader payloads
- Conditionally-active ADCs — CMC considerations for masked antibodies
- Analytical Controls in Early and Late-Stage Process Development
- Methods for quantifying DAR, aggregates, and impurities
- Payload stability assessment during lyophilization and long-term storage
- Linker stability testing — cleavable vs. non-cleavable linkers
- Aggregation and particle analysis
- Potency assays and bioanalytical assays for PKPD activity
- Formulation and Drug Product Manufacturing
- Formulating highly hydrophobic or multipayload ADCs — managing viscosity, aggregation, and solubility
- Stability of conjugates during transport, storage, and on-site
- Subcutaneous and high-concentration conjugate formulations
The deadline for priority consideration is January 23, 2026.
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
Opportunities for Participation: